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Serum uric acid as an index of impaired renal function in congestive heart failure

Yu Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian

老年心脏病学杂志（英文版）2012，Vol.9Issue(2)：137-142,6.
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老年心脏病学杂志（英文版）2012，Vol.9Issue(2)：137-142,6.DOI:10.3724/SP.J.1263.2011.11281

Serum uric acid as an index of impaired renal function in congestive heart failure

Serum uric acid as an index of impaired renal function in congestive heart failure

Yu Tian 1Le Wang 2Li-Shuang Ji 2Guo-Ping Ma 2Kun-Shen Liu 2Chao Liu 2Ying Chen 1Bao Deng 2Gang Liu 2Zhen-Guo Ji 2Qing-Zhen Zhao 2Yu-Zhi Zhen 2Yan-Qiu Gao 2Li Tian3

作者信息

  • 1. Emergency Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China
  • 2. Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China
  • 3. Heart Centre Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China 英文作者简介:
  • 折叠

摘要

Abstract

Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid (UA) metabolism. This study was to assess their potential relations to UA metabolism in heart failure. Methods We retrospectively assessed clinical characteristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure (n = 553). By clustering of indices, those variables were explored using factor analysis. Results In factor analysis, serum uric acid (SUA) formed part of a principal cluster of renal functional variables which included serum creatinine (SCr) and blood urea nitrogen (BUN). Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN (r = 0.48, P < 0.001) and SCr (r = 0.47, P < 0.001). Conclusions There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.

关键词

Serum uric acid/ Heart failure/ Renal function impairment/ Factor analysis

Key words

Serum uric acid/ Heart failure/ Renal function impairment/ Factor analysis

引用本文复制引用

Yu Tian,Le Wang,Li-Shuang Ji,Guo-Ping Ma,Kun-Shen Liu,Chao Liu ,Ying Chen,Bao Deng,Gang Liu,Zhen-Guo Ji,Qing-Zhen Zhao,Yu-Zhi Zhen,Yan-Qiu Gao,Li Tian..Serum uric acid as an index of impaired renal function in congestive heart failure [J].老年心脏病学杂志（英文版）,2012,9(2):137-142,6.

基金项目

The research was funded by Health Bureau of Hebei Province(GL200937). （GL200937）

老年心脏病学杂志（英文版）

OACSCDSCI

1671-5411

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