南京医科大学学报（自然科学版）2012，Vol.32Issue(5)：673-676,4.
人端粒酶逆转录酶在良性前列腺增生、前列腺上皮内瘤及前列腺癌中的表达及其意义
Expression of human telomerase reverse transcriptase in benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostate carcinoma
摘要
Abstract
Objective:To investigate the in situ expression of human telomerase reverse transcriptase (hTERT) in benign prostatic hyperplasia (BPH),prostate intraepithelial neoplasia (PIN) and prostate carcinoma (PCa) tissues and its clinic significance. Methods: Using immunohislochemical method,the expression of hTERT was examined in 43 specimens of prostate tissues,including 15 cases of BPH, 11 cases of PIN and 17 cases of PCa. The association of Cleason score and expression of hTERT was explored. Data were analyzed by Fisher's Exact Test and Spearman's rho analysis. Results: 1. The hTERT protein was expressed in 15 out of 17 PCa cases (88.24%), 4 out of ll PIN cases (36.36%), and Oof 15 cases of BPH . A significant difference of expression was observed in the comparison of each two groups (all P < 0.05). 2. The intensity of hTERT expression in prostate carcinoma increases along with the Gleason score. The intensity of hTERT expression in prostate carcinoma was positively related to the Gleason score (P < 0.05). Conclusion:The hTERT protein is highly expressed in prostate tissue,which may be applied as a biomarker for differential diagnosis between benign and malignant lesions. The intensity of hTERT expression in PCa increases along with the Gleason score. PIN patients with positive expression of hTERT should be closely observed and fellowed up.关键词
人端粒酶逆转录酶/良性前列腺增生/前列腺上皮内瘤/前列腺癌/免疫组化Key words
human telomerase reverse transcriptase/benign prostatic hyperplasia/prostate intraepithelial neoplasia/prostate carcinoma/ immunohistochemirtry分类
生物科学引用本文复制引用
毕磊,陈方敏,石家齐,严波,肖峰,范诗秋..人端粒酶逆转录酶在良性前列腺增生、前列腺上皮内瘤及前列腺癌中的表达及其意义[J].南京医科大学学报（自然科学版）,2012,32(5):673-676,4.基金项目
国家自然科学基金(30860284) （30860284）
贵州省优秀科技教育人才省长专项资金[黔省专合字2007(76)号] （76）
