中国海洋大学学报（自然科学版）2012，Vol.42Issue(5)：60-67,8.
解脂耶罗维亚酵母(Yarrowia lipolytica)的代谢工程
Recent Progress in Metabolic Engineering of Yarrowia lipolytica
摘要
Abstract
In the article, the latest progress on metabolic engineering of Yarrowia lipolytica is presented Y. lipolytica is non-pathogenic (GRAS, generally regarded as safe), widely distributed in various environments including marine and polar region, also, it has an excellent expression, system, some strains of it can accumulate proteins or oils, or secrete citric acid. Furthermore, it has been reported that Y. lipolytica is capable of secreting two natural proteases (alkaline extracellular protease and acid protease) and degradates hydrocarbons. It was found that after the yeast cells are genetically modified, some renewable materials such as inulin can be used by the enginnered yeasts. The engineered yeasts can use inulin to accumulate protein and oils and secrete citric acid. Many industrially important enzymes can be synthesized by the engineered yeasts. Therefore, the metabolically engineered Y. lipolytica can be widely used in bioenergy, food, pharmaceutical and marine cultural industry.关键词
脂耶罗维亚酵母/代谢工程/表面展示质粒/生物油脂/柠檬酸Key words
Yarrowia lipolytica/ metabolic engineering/ surface display vector/ single cell oil/ citric acid分类
生物科学引用本文复制引用
池振明,赵新灵,王凌飞..解脂耶罗维亚酵母(Yarrowia lipolytica)的代谢工程[J].中国海洋大学学报（自然科学版）,2012,42(5):60-67,8.基金项目
国家海洋局公益项目(201005032)资助 （201005032）
