冯仕品 1王莉 1谢敏 1罗苇 1张伟 1金梅 1杨胜1
作者信息
- 1. 成都市妇女儿童中心医院儿童肾内科,四川成都610091
- 折叠
摘要
Abstract
To explore the relationship of clinical characteristic and renal biopsy in pediatric lupus nephritis. Methods To analyze retrospectively the clinic manifestations, laboratory and pathological data in 20 cases of children with lupus nephritis. Results The clinic type with nephritic syndrome was the most common, accounting for 8 cases(40% ) ,isolated hema-turia or ( and ) proturia were 4 cases( 10% ) .acute nephritis were 4 eases(20% ) .rapidly progressive glomerulonephritis were 2 cases (10%) .chronic nephritis was 1 cases(5% ) .renal tubular interstitial damage were 2 cases(10%) ,8ubclinical type was 1 case ( 5 % ). There were more extrarenal symptoms with fever( 65 % ), anemia( 35 % ), skin lesion (50% ), arthritis (35 % ). In laboratory data, there were complement C3 decreased in 17 cases ( 85% ) , antinuclear antibody (ANA) positive in 16 caaes(80%), ds-DNA positive in 13 (65% ) .plasma albumin decreased in 8 cases(40%), transaminase increased in 4 cases(20% ) ,Hb decreased in 13 cases(65% ) , leukocyte reduction in 11 cases (55% ) .thrombocytopenia in 9 cases (45% ) .blood urea nitrogen increased in 7 cases (35% ) ,D two dimmer positive in 9 cases (45% ) .Coob's test positive in 3 cases ( 15% ) .globulin increased in 4(20% ) , ESR increased in 3(15% ). 20 cases of renal biopsy were abnormal, in which type IV was the most, accounting for 50% (10 cases) , followed by type V (3 cases )accounted for 15% , type I ,type I and type III (1 cases each) accounted for 5% each, type TV plus V (2 cases )accounted for 10% , type III plus V (2 cases) accounted for 10%. In most renal pathology of the patients, immune fluorescence was "a bright" , 2 cases showed less immune complex deposit. Conclusion The clinic manifestations and pathological types of Lupus nephritis in children have their own characteristics, the renal pathology examination has a very important guiding role to the diagnosis and treatment of lupus nephritis.关键词
狼疮性肾炎/肾活检/肾脏病理/儿童Key words
lupus nephritis/ renal biopsy/renal pathology /children分类
医药卫生
