山东医药2012，Vol.52Issue(13)：35-37,3.
己酮可可碱对人食管癌细胞EC9706的5-Fu化疗增敏作用
Pentoxifylline enhances chemotherapy sensitization of 5-Fu in human esophageal carcinoma EC9706 cell
摘要
Abstract
Objective To investigate Pentoxifylline effect on chemotherapy sensitization of 5-Fu in human esophageal carcinoma EC9706 cell. Methods MTT method was used to determine the inhibition effects of 5-Fu and PTX uniting S-Fu to EC9706 Cell line. Results The EC9706 cells were treated by different concentration of 5-Fu and S-Fu uniting PTX for 12 h, 24 h, 48 h and 72 h. There were significant difference in inhibition rates in each group at the same time(P<0.01). The inhibition of S-Fu to EC9706 cells was gradually increasing along with the ascending of PTX concentration; There was no significant difference between the 0.5 mg/mL PTX or 1.0 mg/mL PTX uniting S-Fu 25 μg/mL and only 50 μg/mL 5-Fu at 24 h, 48 h and 72 h(all P>0.05). Conclusion PTX makes the EC9706 cells more sensitive to 5-Fu, and decrease dose of 5-Fu.关键词
食管肿瘤/氟尿嘧啶/己酮可可碱Key words
esophageal/ Quorouracil/ pentoxifylline分类
医药卫生引用本文复制引用
宋慧琴,李道明..己酮可可碱对人食管癌细胞EC9706的5-Fu化疗增敏作用[J].山东医药,2012,52(13):35-37,3.基金项目
河南省医学科技攻关项目资助课题(200803035). （200803035）
