IL-1O单核苷酸多态性与溃疡性结肠炎的相关性研究OACSTPCD
The relationship between IL-10 gene polymorphisms and ulcerative colitis
目的 探讨血清IL-10水平、IL-10启动子区3个位点(IL-10 - 1082/- 819/- 592)的单核苷酸多态性(SNPs)与溃疡性结肠炎之间的相关性.方法 选择溃疡性结肠炎患者60例(溃疡性结肠炎组),轻度24例、中一重度36例,并设健康对照组.采用ELISA法检测血清中IL-10,采用PCR-RFLP检测1L-10启动子区SNPs.结果 中一重度溃疡性结肠炎患者血清IL-10水平低于健康对照组(P＜0.05).溃疡性结肠炎组IL-…查看全部>>
Objective To study the relationship among serum expression of IL-10, three sites (IL-10 - 1082/-819/ -592) of the SNPs in IL-10 promoters, and ulcerative colitis( UC). Methods Sixty UC patients were chosed as UC group, in which 24 cases were mild, 36 cases were moderate to severe, healthy subjects were chosed as control group. Serum expressions of IL-10 were analyzed by ELJSA, the SNPs in IL-10 promoters were analyzed by PCR-RFLP. Results The expressions of …查看全部>>
李贞娟;张彩凤;韩宇;文廷玉;董良鹏;张秀英
新乡医学院第一附属医院,河南卫辉453100新乡医学院第一附属医院,河南卫辉453100新乡医学院第一附属医院,河南卫辉453100新乡医学院第一附属医院,河南卫辉453100新乡医学院第一附属医院,河南卫辉453100新乡医学院第一附属医院,河南卫辉453100
医药卫生
结肠炎,溃疡性白细胞介素10多态性,单核苷酸
cols,ulcerative IL-10 polymorphisms, single nucleotide
《山东医药》 2012 (13)
49-51,3
河南省教育厅科研基金资助项目(20073200143).
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