山东医药2012，Vol.52Issue(15)：8-11,4.
广西红水河流域长寿人群CETPTaqIB基因多态性、血脂水平及相关性分析
CETPTaqIB polymorphism and its association with lipid levels of long-lived inhabitants in Guangxi Hongshuihe River Basin
摘要
Abstract
Objective To investigate the TaqlB polymorphism of the cholesterol ester transfer protein gene ( CETP) and its possible association with lipid levels and longevity in Guangxi Hongshuihe River Basin. Methods The polymorphism of CETPTaqIB locus was genotyped by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP), physical examinations including blood pressure, body weight, height, body weight index were performed and serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein ( HDL), low density lipoprotein (LDL) levels were measured for 523 Zhuang long-lived inhabitants (aged 90 and above, longevity group) and 498 ethnicity matched healthy controls (aged 40-69, control group) residing in Hongshuihe River Basin. Results The overall allelic and genotypic frequencies of the cohorts studied were B1 63.47%, B2 36. 53% , B1B1 38.49% ,B1B2 49.95% ,B2B2 11.56% , respectively. No difference in allelic and genolypic frequencies was found between the longevity group and control group (P>0.05). However, in lipid profiles, the levels of TC, HDL and LDL were significantly higher in the longevity group than those in the control group; the HDL levels of genotype B2B2 and B1B2 carriers were found remarkably higher than that of the Bl Bl carriers within the longevity group; the HDL level of Bl Bl carriers and the LDL level of all the three genotypes were greatly increased while the TG level of any genotype were reduced in the longevity group as compared with the control group. Conclusions The polymorphism of the CETP TaqlB locus is highly correlated with the lipid levels, which might be one of the genetic basis of longevity in the area of Guangxi Hongshuihe River Basin关键词
胆固醇酯转移蛋白/长寿/脂蛋白/基因多态性Key words
cholesterol ester transfer protein/ longevity/ lipoprotein/ genetic polymorphism分类
医药卫生引用本文复制引用
王菲,黄龄瑾,尹瑞兴,潘尚领,吕泽平,刘承武,胡才友,彭均华,罗晓秋,庞国防,卢少华,吴华裕..广西红水河流域长寿人群CETPTaqIB基因多态性、血脂水平及相关性分析[J].山东医药,2012,52(15):8-11,4.基金项目
国家自然科学基金资助项目(31160209 （）
30860126). （）
