山东医药2012，Vol.52Issue(15)：39-41,3.
As2O3预处理对离体缺血再灌注心肌的保护作用及机制
Protective effect of As2O3 preconditioning on isolated hearts with ischemia-reperfusion injury and its mechanism
摘要
Abstract
Objective To investigate the mechanism of the inhibiting effect of As2O3 preconditioning on heat shock protein (HSP)27 during ischemia/reperfusion injury (IRI) in isolated rat hearts. Methods Sixteen rats with IRI were divided into observed group and control group with 8 in each, the observed group was given As2O3 preconditioning by intrap-eritoneal injection, and the control group was given normal saline. The ventricular function, infaret size, ultrastructure changes and the expression of HSP27 were measured. Results Compared with control group, the LVEDP, LV +dP/dtmax and LV-dP/dlmax improved significantly, the ultrastructure injury lightened, while the expression of HSP27 increased obviously (all P<0.01). Conclusion As2O3 preconditioning can protect hearts with ischemia-reperfusion injury, the mechanism maybe related to increase the expression of HSP27.关键词
三氧化二砷/缺血再灌注/心肌损伤/热休克蛋白Key words
arsenic dioxide/ ischemia/ myocardium/ heat shock protein分类
医药卫生引用本文复制引用
王方岩,戴雍月,方周溪,郝卯林,汪洋..As2O3预处理对离体缺血再灌注心肌的保护作用及机制[J].山东医药,2012,52(15):39-41,3.基金项目
温州市科技局科研基金资助项目(y20070085). （y20070085）
