山东医药2012，Vol.52Issue(17)：7-9,3.
利拉鲁肽对糖耐量异常大鼠血清炎症指标的影响
Effect of liraglutide on the serum inflammatory markers in impaired glucose tolerance OLETF rats
摘要
Abstract
Objective To investigate the effect of liraglutide on the serum inflammatory markers in impaired glucose tolerance OLETF (IGT-OLETF) rate. Methods A total of 29 IGT-OLETF rats were randomly divided into four groups. They were treated with a single intraperitoneal injection of either saline vehicle (NS group, n = 8) or liraglutide ( 50 )μg/kg group, n = 8; 100 μg/kg group, n=6; or 200 μg/kg group, n = 7; respectively) twice daily for 12 weeks. Eight LETO rats received saline vehicle intraperitoneal injection twice daily for 12 weeks and served as the normal control group. After 12-week intervention, blood glucose, islet cell function and insulin sensitivity (including: fasting blood glucose, insulin, insulin sensitivity index, insulin resistance index and islet beta cell function), and inflammatory markers (including: IL-6, high-sensitivity C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen) were measured. Results Compared with the NS group, the blood glucose, islet cell function and insulin sensitivity were significantly improved and the serum inflammatory markers were significantly decreased in liraglutide-treated group (all P <0.05). Conclusions Liraglutide has anti-inflammatory effect, can improve islet cell function and insulin sensitivity, and decreases theserum inflammation markers in IGT-OLETF rats, which has the potential role to prevent diabetes and cardioascular disease.关键词
糖尿病/糖耐量异常/利拉鲁肽/炎症指标/大鼠Key words
diabetes, mellitus/ impaired glucose tolerance/ liraglutide/ inflammatory markers/ rats分类
医药卫生引用本文复制引用
郭南京,孙嘉,湛奕,陈宏,张桦,蔡德鸿..利拉鲁肽对糖耐量异常大鼠血清炎症指标的影响[J].山东医药,2012,52(17):7-9,3.基金项目
中华国际医学交流基金会β-cell Academy研究资助项目(2100325) （2100325）
广东省医学科研技术研究基金资助项目(B2011207). （B2011207）
