山东医药2012，Vol.52Issue(18)：27-29,3.
糖尿病ED大鼠阴茎海绵体中血红素加氧酶的表达变化及意义
Expression change and significance of heme oxygenase in the corpus cavernosum of diabetic rats with erectile dysfunction
摘要
Abstract
Objective To investigate the expression of heme oxygenase 1 and 2 in the corpus cavemosum of diabetic rats with erectile dysfunction. Methods Forty male adult Sprague-Dawley rats were divided into two groups randomly: 10 as normal control and 30 used to induce diabetes mellitus( DM) with intraperiitoneal injection of freshly prepared slreptozo-tocin (65 mg/kg). 8 weeks later, the erectile function of DM rats were evaluated by subcutaneous injection with apomor-phine (80 μg/kg), diabetic rats which showed erectile dysfunction were as DM-ED group; and the other were as DM group, the distribution and expression level of HO-1 and HO-2 in the penile tissues of all raU were examined by immuno-histochemistry and Western blot. Results HO-1 and HO-2 protein expression were demonstrated in the penis tissue of all rats. The HO-1 and HO-2expression level in NC group were 11. 38 ± 1. 77,27.69 ± S. 07; DM group were 8.49 ± 4.74, 16.41 ±2.75 ; DM-ED group were 18.02 ±3.19,7.04 ±2.94. The difference of HO-1 and HO-2 expression between DM and DM-ED group, DM and NC group, DM-ED and NC group was statistically significant (all P<0.05). Conclusions The expression of HO-1 increase and HO-2 decreased in in the corpus cavemoaum of diabetic rats with erectile dysfunction. Both may participate the development machnism of diabetes mellitus leading to ED.关键词
勃起功能障碍/糖尿病/血红素加氧酶/阴茎海绵体/大鼠Key words
erectile dysfunction/ diabetes mellitus/ heme oxygenase/ corpus cavemosum/ rats分类
医药卫生引用本文复制引用
刘丁乙,姜华茂,王全刚,朱家亮,王海鹏..糖尿病ED大鼠阴茎海绵体中血红素加氧酶的表达变化及意义[J].山东医药,2012,52(18):27-29,3.基金项目
辽宁省高等学校优秀人才支持计划资助项目(LJQ2011088). （LJQ2011088）
