实验动物与比较医学2012，Vol.32Issue(2)：133-136,141,5.DOI:10.3969/j.issn.1674-5817.2012.02.011
薏苡仁油注射液对人体肝癌SMMC-7721裸鼠异种移植模型的抑制作用
The Inhibiting Effect of Coix Seed Oil Injection on Xenograft Model of Human Liver Cancer Cell SMMC-7721
摘要
Abstract
Objective To study the inhibiting effect of coix seed oil injection on human live cancer SMMC-7721 grafted in nude mice. Methods The model of human live cancer SMMC-7721 grafted in nude mice was established, the tumor size and body weight of mice bearing tumors were observed and measured, then relative tumor growth rates and tumor inhibition rates calculated. After the last treatment, tumors and various organs were harvested for immunohistochemistry and HE staining. Result The relative tumor growth rates of three dose groups of coix seed oil injection were 33.02%, 35.78% and 39.41%, and the inhibition rates were 49.54%, 46.86% and 41.71% respectively. The positive Ki-67 staining rate of tumors in nude mice treated with coix seed oil injection was significantly lower than that in the control group. Main organs showed normal state according to hematoxylin and eosin staining. Conclusion Coix seed oil injection has certain inhibition efficacy on the xenograft model of human liver cancer cell SMMC-7721.关键词
薏苡仁油注射液/SMMC-7721/裸鼠Key words
Coix seed oil/ SMMC-7721/ Nude mice分类
生物科学引用本文复制引用
尹蓓珮,陆宏祺,沈龙海,李炳生..薏苡仁油注射液对人体肝癌SMMC-7721裸鼠异种移植模型的抑制作用[J].实验动物与比较医学,2012,32(2):133-136,141,5.基金项目
国家"重大新药创制"科技重大专项资助(项目编号:2009ZX09301-007) （项目编号:2009ZX09301-007）
