实验动物与比较医学2012，Vol.32Issue(2)：170-174,5.DOI:10.3969/j.issn.1674-5817.2012.02.020
5-LO/FLAP与冠心病相关性的研究进展
Advances in Research on Relationship between 5-LO/FLAP and Coronary Artery Disease
摘要
Abstract
Coronary artery disease(CAD) is one of the cardiovascular disease that harmful to human health in the world nowadays. The pathogenesis of CAD is very complicated and until now it has not been completely clarified, the concept that CAD is a chronic inflammatory disease of the coronary artery, is now well accepted. Leukotrienes(LTs) are important inflammatory mediators, which play a strong role in promoting inflammatory reaction. 5-lipoxygenase (5-LO) is the key enzyme in the forming process of leukotrienes(LTs), while the 5-lipoxygenase activating protein(FLAP) is necessary if the 5-LO needs to be activated. Recent studies have found that 5-LO/FLAP play important roles in the formation and development of CAD. In this review, mainly focused on the relationship between 5-LO/FLAP and CAD.关键词
冠心病/5-脂氧合酶/5-脂氧酶激活蛋白/白三烯/炎症反应Key words
Coronary Artery Disease/ 5-lipoxygenase/ 5-lipoxygenase activating protein/ Leukotriene/ Inflammation分类
生物科学引用本文复制引用
刘志华,陈民利..5-LO/FLAP与冠心病相关性的研究进展[J].实验动物与比较医学,2012,32(2):170-174,5.基金项目
卫生部科研基金(WKJ2009-2-032),"浙江省卫生高层次创新人才培养工程项目"资助 （WKJ2009-2-032）
