实验动物与比较医学2012，Vol.32Issue(3)：218-221,4.DOI:10.3969/j.issn.1674-5817.2012.04.010
IL-12对辐射损伤后小鼠造血干细胞的修复作用
IL-12 Facilitate the Recovery of Hematopoietic Stem Cells after Ionizing Radiation in Rat
王翠玲 1王增松 1夏书奇 1郭桂铃 1谢飞群 1李文棠 1牛丽红 1罗群芳 1张宜俊1
作者信息
- 1. 广州市恺秦生物科技有限公司,广州510620
- 折叠
摘要
Abstract
Objective The ability of recombinant murine interleukin-12 (rmIL-12) to facilitate recovery of bone marrow hematopoietic stem cells (HSC) from irradiation in mice model were evaluated. Method The rmIL-12 treated SPF BALB/c mice or bone marrow hematopoietic stem cells obtained from the animals before and after irradiation were examined for the viable counts and apoptosis of bone marrow hematopoietic stem cells. Results The rmIL-12 treatment before and after irradiation was effective to increase hematopoietic stem cells of suppressed bone marrow and reduce apoptosis both in obtained hematopoietic stem cells and in mice. Conclusion The rmIL-12 had obvious effect on recovery of hematopoietic stem cells from irradiation induced damage. Moreover, this study provided experimental evidence for IL-12 as clinic therapy to treat diseases associated with hematopoietic cytopenia.关键词
rmIL-12/小鼠骨髓造血干细胞/照射/干细胞数量/凋亡率Key words
rmIL-12/ Mice/ Bone Marrow/ Hematopoietic Stem Cell/ Irradiation/ Stem Cell Counts/ Apoptosis分类
生物科学引用本文复制引用
王翠玲,王增松,夏书奇,郭桂铃,谢飞群,李文棠,牛丽红,罗群芳,张宜俊..IL-12对辐射损伤后小鼠造血干细胞的修复作用[J].实验动物与比较医学,2012,32(3):218-221,4.
