同济大学学报（医学版）2012，Vol.33Issue(2)：47-49,3.DOI:10.3969/j.issn1008-0392.2012.02.010
太白楤木总皂苷体外对乙肝病毒HBsAg、HBeAg的影响
Inhibitory effects of total saponin extracted from Aralia chinesis L on hepatitis virus B in vitro
摘要
Abstract
Objective To investigate the inhibitory effects of total saponin extracted from Aralia chinesis L. on hepatitis B virus in vitro. Methods HepG 2215 cells as target cells were exposed to different concentrations of total saponin of Aralia chinesis L. or lamivudine. Enzyme-linked immunosorbent assay was used for determining the HBsAg and HBeAg in supernatants of cell culture. Results The 50% inhibitory concentration (IC50) of total saponin on HBsAg and HBeAg production was 0. 1 and 0. 09 g/L, respectively; therapeutic index was 6. 12, 7. 51 respectively. There were no significant differences in inhibitory effects on HBsAg and HBeAg production between 0. 4 g/L of total saponin and 0. 25 g/L of lamivudine at d3 and d6 of treatment. Conclusion The total saponin extracted from Aralia chinesis L has inhibitory effects on HBV replication in vitro to some extent.关键词
太白楤木/HepG 2215细胞/肝炎病毒,乙型Key words
Aralia Chinesis Saponis/ HepG 2215 cell/ hepatitis B virus分类
医药卫生引用本文复制引用
崔大江,杨渭临,李秀丽..太白楤木总皂苷体外对乙肝病毒HBsAg、HBeAg的影响[J].同济大学学报（医学版）,2012,33(2):47-49,3.基金项目
陕西省科学技术研究发展计划[2005k16-G(3)] （3）
