同济大学学报（医学版）2012，Vol.33Issue(2)：54-57,4.DOI:10.3969/j.issn1008-0392.2012.02.012
降钙素对骨质疏松性骨内种植体骨生物力学性能的影响
Effect of calcitonin on biomechanical characteristics of osteoporotic bone with implant
毛永灵 1陆卫青2
作者信息
- 1. 上海市闵行区牙病肪治所,上海201103
- 2. 同济大学附属同济医院口腔科,上海200065
- 折叠
摘要
Abstract
Objective To investigate the effect of calcitonin on biomechanical characteristics of osteoporotic bone with implant. Methods The osteoporosis model was induced by ovariectomy in female New Zealand rabbits. Seventy-two rabbits were randomly divided into three groups with 24 in each group: in normal control group (NC) animals received intramuscular injection of normal saline 0.4 ml/d×4 d, in osteoporosis group (OP) a pure titanium screw was implanted in the proximal tibial metaphysis in castrated animals and received intramuscular injection of normal saline, in calcitonin group (CT) the animals received both titanium implant and intramuscular injection of calcitonin 4 u/d ×4 d. Eight specimens were harvested from each group at week 2, 4 and 8; biomechanical characteristics including bend load (BL) and maxillary tensile length (TL max) were evaluated. Results The BL in NC group was highest, followed by CT group, and that in OP group was lowest at all time points. The TL max of NC group was shortest, followed by CT group, and that of OP group was longest at all time poits. There were significant differences among these groups (P < 0.01). Conclusion Calcitonin can improve the biomechanical characteristics of osteoporotic bone with implant.
关键词
骨质疏松症/种植体/降钙素/生物力学Key words
osteoporotic/ implant/ calcitonin/ biomechanic分类
医药卫生引用本文复制引用
毛永灵,陆卫青..降钙素对骨质疏松性骨内种植体骨生物力学性能的影响[J].同济大学学报（医学版）,2012,33(2):54-57,4.
