世界中医药2012，Vol.7Issue(4)：362-364,3.
寿胎丸提取液透过妊娠大鼠胎盘屏障的药物成分研究
Study on ingredients of Shou Tai Wan extract through placental barrier of rat in pregnancy
摘要
Abstract
Objective: Use HPLC to studty the permeation of ingredients of Shou Tai Wan extract( STW ) through placental barriers of Wistar rats at different stages of pregnancy. Methods:The pregnant rats were administered by gavage STW for 5 days at early,middle and late stages of pregnancy. Hepatic portal vein plasma, umbilical veins plasma ( at late stage of pregnancy ) and embryonic tissues were obtained 1 h,12 h after the final administration of STW. The compounds in biological specimens were identified by HPLC. Results:Among the range of experimental doses, loganin and quercitrin were main compounds in 1 h maternal blood but nothing could examined in 12 h maternal blood,umbilical veins plasma and embryonic tissues at different stages of pregnancy. Conclusion:Under the range of experimental doses,the compounds of STW didn't permeate through placental barriers of rats. This result showed that the application of STW is safe to embryo in pregnancy.关键词
寿胎丸/马钱子苷/槲皮苷/胎盘屏障/HPLCKey words
Shou Tai Wan/ Loganin / Quercitrin/ Placental barrier/ HPLC引用本文复制引用
邓丽丽,宋殿荣,胡丽萍,王跃飞..寿胎丸提取液透过妊娠大鼠胎盘屏障的药物成分研究[J].世界中医药,2012,7(4):362-364,3.基金项目
国家科技部中医药行业专项(编号:200707011) （编号:200707011）
