生命科学研究2012，Vol.16Issue(2)：102-107,6.
不同强度运动对大鼠心肌细胞凋亡的影响
The Effect of Different Load Exercise on Myocardial Apoptosis in Rats
摘要
Abstract
This research attempts to find out the general rules of relationship by comparing the myocardial cell apoptosis of rats in different strength exhaustion movement and the charging manifestations of related gene B cell lymphoma-2 (Bcl-2).Thereby the research provides the theoretical basis for formulating appropriate and reasonable load of exercise in training.With the subjects of 30 male SD rats aged 8 weeks, the research randomly divides the rats into such 3 groups as normal control group (NC), moderate intensity exercise group (ME) and high intensity group (HE).The determination of the myocardial cell apoptosis index and related gene Bcl-2 is based on the method of myocardial cell dyeing.The final result indicates that there is a phenomenon of myocardial cell apoptosis in both ME and HE groups. The myocardial cell apoptosis index remarkably increases in ME group with a significant difference(P＜0.05) and the differences between different exercise groups are statistically insignificant. There are manifestations of Bcl-2 in three groups, the comparison made between ME and NC groups indicates significant different (P＜0.01), so does the comparison between HE and NC groups(P＜0.05).The manifestations in HE group are obviously fewer than those in ME group (P＜0.05). Therefore, the thesis comes to a conclusion that inappropriate load in sports will lead to more myocardial cell apoptosis of rats and might even be involved in the process of myo-cardial damage.关键词
运动/心肌/细胞凋亡/B细胞淋巴瘤-2Key words
exercise/ myocardial/ apoptosis/ Bcl-2分类
生物科学引用本文复制引用
陈淦,汤长发..不同强度运动对大鼠心肌细胞凋亡的影响[J].生命科学研究,2012,16(2):102-107,6.基金项目
湖南省自然科学基金资助项目(10JJ6041) （10JJ6041）
