陕西医学杂志2012，Vol.41Issue(8)：939-941,3.
异氟烷预处理对脑缺血再灌注大脑保护作用的实验研究
Protective Effects of Isoflurane on Cerebral Injury from Cerebral Ischemia-reperfusion in Rats
来炳祺 1苏伟 1叶荣1
作者信息
- 1. 陕西省肿瘤医院麻醉科,西安,710061
- 折叠
摘要
Abstract
Objective; To study the protective effects of isoflurane on cerebral injury from cerebral ischemia-reperfusion in rats. Methods; 20 rats were randomly divided into two groups with 10 rats each group. The two groups were performed basic anesthesia with ketamine (1mg/kg). Direct surgery for control group, while experimental group were inhalationally anesthetized with isoflurane to maintain anesthesia during surgery at the same time. In two groups after cerebral ischemia-reperfusion, cerebral tissues were sampled. Observed morphological changes of the lung tissues and determined NF-ΚB in cerebral tissue. Results; Isoflurane anesthesia during cerebral ischemia-reperfusion in rats was effective in reducing NF-ΚB in cerebral tissue,and cerebral tissue damage became attenuated. Conclusion; Isoflurane was effective to cerebral injury from cerebral ischemia-reperfusion in rats.关键词
脑缺血/并发症/再灌注损伤/异氟烷/动物,实验/大鼠Key words
Brain ischemia/complications/ Reperfusion injury/ @ Isoflurane/Animals, laboratory Rats分类
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来炳祺,苏伟,叶荣..异氟烷预处理对脑缺血再灌注大脑保护作用的实验研究[J].陕西医学杂志,2012,41(8):939-941,3.
