物理学报2012，Vol.61Issue(11)：319-326,8.
高灵敏度集成光偏振干涉仪特性及生化传感应用研究
Characterization and chemical/biosensing application of a high-sensitivity integrated optical polarimetric interferometer
摘要
Abstract
A tapered thin film of Ta2O5 is sputtered on a single-mode slab glass waveguide to form a composite optical waveguide（COWG） for serving as a prism-coupled integrated optical polarimetric interferometer.The relationship between the refractive-index sensitivity （Sri） of the interferometer and the equivalent thickness（Toq） for the tapered layer of Ta2O5 is theoretically analyzed based on a fourlayer homogeneous waveguide model.A comparison of the measured Sri with the simulated data leads to Teq≈33.021 nm for the COWG used.The sensitivity of the interferometer to thickness of the protein adlayer is determined to be Sad≈（2.412×2n）/nm. The acetic-acid concentration of a commercial Chinese vinegar is investigated,for the first time,by use of the interferometer combined with the Lorentz-Lorenz effective-medium theory.Water and methanol adulterations of a commercial Chinese liquor are detected with the interferometer.The results indicate that the refractive-index change induced by the adulteration is a quasi-linear function of the adulteration amount.Both the dynamic adsorption process of butyrylchohnesterase and the self-assembly process of cytochrome c/PSS multilayer film are monitored in real time with the sensor.The protein surface coverage is obtained from the combination of the measured phase-difference change and the adlayer-thickness sensitivity.关键词
复合光波导/偏振干涉/高灵敏度/生化检测Key words
composite optical waveguide/polarimetric interferometry/high sensitivity/chemical biosensing分类
信息技术与安全科学引用本文复制引用
逯丹凤,祁志美..高灵敏度集成光偏振干涉仪特性及生化传感应用研究[J].物理学报,2012,61(11):319-326,8.基金项目
国家自然科学基金 （）
国家重点基础研究发展计划 （）
中国科学院百人计划基金资助的课题 （）
