新医学2012，Vol.43Issue(7)：460-463,4.DOI:10.3969/g.issn.0253-9802.2012.07.008
静脉注射与口服骨化三醇冲击治疗腹膜透析患者继发性甲状旁腺功能亢进的疗效比较
Comparison of intravenous and oral pulse administration of calcitriol in treatment of peritoneal dialysis patients with secondary hyperparathyroidism
摘要
Abstract
Objective: To evaluate the clinical efficacy of intravenous and oral pulse administration of calcitriol on treatment of peritoneal dialysis patients with secondary hyperparathyroidism ( SHPT) . Methods: Fifty-eight peritoneal dialysis patients with serum intact parathyroid hormone (iPTH) higher than 300 ng/L were randomly divided into intravenous pulse group ( Group A) and oral pulse group ( Group B ). The dosage of calcitriol was ad -justed according to individual iPTH level. Serum iPTH, alkaline phosphatase ( AKP) , calcium and phosphorus were measured after calcitriol treatment, the side effects were also recorded. Results:The serum iPTH was significantly reduced in both groups (P <0. 05). The normal iPTH rates in Group A 4, 8 and 12 weeks after treatment were 41% , 83% and 97% , respectively, while they were 28% , 66% and 90% , respectively, in Group B, with significant differences revealed between the two groups ( P < 0. 05 ). There was no significant difference in serum phosphorus or calcium-phosphorus product between the two groups before or after treatment . No adverse event was reported. Conclusions: Although calcitriol with Intravenous and oral pulse administration are safe and effective for peritoneal dialysis patients with SHPT , the former provides higher efficacy.关键词
骨化三醇/慢性肾衰竭/腹膜透析/继发性甲状旁腺功能亢进Key words
Calcitriol/ Chronic renal failure/ Peritoneal dialysis/ Secondary hyperparathyroidism引用本文复制引用
吴素红,崔惠敏,刘远浩..静脉注射与口服骨化三醇冲击治疗腹膜透析患者继发性甲状旁腺功能亢进的疗效比较[J].新医学,2012,43(7):460-463,4.
