疑难病杂志2012，Vol.11Issue(9)：668-670,3.DOI:10.3969/j.issn.1671-6450.2012.09.007
慢性乙型肝炎肝脂肪变的相关因素分析
The relationship between chronic hepatitis B and hepatic fatty degeneration
王明芳 1林苏 1陈靖 1江家骥1
作者信息
- 1. 350005,福州,福建医科大学附属第一医院肝病中心
- 折叠
摘要
Abstract
Objective To investigate the relationship between chronic hepatitis B ( CHB ) and hepatic fatty degeneration. Methods 1039 patients with biopsy proven CHB were reviewed in the study. Biological chemical index, liver histology and body mass index ( BMI ) were examined in these patients. Results A total of 1039 CHB patients ( 843 men ) with a mean age of ( 37 ± 11 ) years were analyzed. Hepatic fatty degeneration was present in 375 ( 36. 1% ) patients. The prevalence of hepatic fatty degeneration in male patients was significantly higher than that in female patients ( 38. 8% vs. 24. 5% , P < 0.01 ). Age, BMI, uric acid ( UA ), cholesterol ( TC ), triglyceride ( TG ), apolipoprotein A ( ApoA ), apolipoprotein B ( ApoB ) and the occurrence of metabolic syndrome were significantly higher in CHB patients with hepatic fatty degeneration than those without hepatic fatty degeneration ( P < 0. 05 ). No significant difference was found in serum HBeAg status or HBV-DNA titer( P >0. 05 ). The multivariate correlation displayed that the severity of hepatic fatty degeneration was positive related to the BMI and TG ( p = 0. 323 , p = 2. 255 , P < 0. 01 ), and was negative related to the level of AFP ( p = - 0. 008 , P <0. 05 ). Conclusion Hepatic fatty degeneration is common found in CHB. It is associated with metabolic factors than virus factors. The existence of hepatic fatty degeneration dose not exacerbate liver inflammation or fibrosis.关键词
乙型肝炎,慢性/肝脂肪变/相关分析Key words
Hepatitis B,chronic/ Hepatic fatty degeneration/ Correlation analysis引用本文复制引用
王明芳,林苏,陈靖,江家骥..慢性乙型肝炎肝脂肪变的相关因素分析[J].疑难病杂志,2012,11(9):668-670,3.
