疑难病杂志2012，Vol.11Issue(9)：679-681,3.DOI:10.3969/j.issn.1671-6450.2012.09.011
新辅助化疗对子宫内膜癌VEGF mRNA表达的影响
Influence of neoadjuvant chemotherapy on VEGF mRNA expression in endometrial carcinoma
摘要
Abstract
Objective To analysis the influence of neoadjuvant chemotherapy on VEGF mRNA expression in endometrial carcinoma. Methods 180 patients with endometrial carcinoma in the hospital who reached the project standard were enrolled, they were clinically diagnosed, and randomly divided into the observation group and the control group ( 90 cases in each group ). Patients in the control group using conventional chemotherapy after operation, the patients in the observation group received neoadjuvant chemotherapy. Comparing the two groups of patients after treatment, the clinical effect, incidence of adverse reactions, VEGF mRNA expression difference were observed and recorded. Results The general information in observation group and the control group patients such as age, course of disease, and staging have no statistical difference ( P > 0. 05 ); the total efficiency of patients in the observation group was significantly higher than that in control group ( 83. 3% vs 65.5% , P < 0. 05 ); VEGF mRNA expression of each stage in the observation group was lower than that in control group ( P < 0. 05 ), the total incidence of adverse reaction in observation group was significantly lower than that in control group ( 14.4% vs 34.4% , P <0. 05 ). Conclusion Neoadjuvant chemotherapy can effectively reduce the VEGF mRNA expression, improve its clinical efficacy, and reduce the occurrence of adverse reactions.关键词
新辅助化疗/子宫内膜癌/血管内皮生长因子/信使核糖核酸Key words
Neoadjuvant chemotherapy/ Endometrial carcinoma/VEGF/ mRNA引用本文复制引用
张和平,金海红,王智文,史红珍,李小平..新辅助化疗对子宫内膜癌VEGF mRNA表达的影响[J].疑难病杂志,2012,11(9):679-681,3.基金项目
国家自然科学基金(№.30973181) （№.30973181）
