医药导报2012，Vol.31Issue(5)：578-580,3.DOI:10.3870/yydb.2012.05.007
凝血酶-壳聚糖海藻酸钠微球止血作用研究
Hemostatic Effect of Thrombin -Chitosan Sodium Loaded Alginate Microspheres
王强 1郎轶咏 1李峥 1戴华1
作者信息
- 1. 解放军第202医院药剂科,沈阳110003
- 折叠
摘要
Abstract
Objective To investigate the hemostatic effect of alginate microspheres with thrombin-chitosan sodium. Methods The hemostatic microspheres were prepared by emulsion-crosslinking method, with chitosan sodium and alginate as excipients, thrombin as model drug. The models of trauma caused femoral artery bleeding in rats .blood oozing from the back of rats and bleeding from broken tails of mice were created, the model animals were treated with thrombin microspheres and compared with Yunnan Baiyao and tampons. The hemostatic time and bleeding volume were recorded to assess the hemostatic effect of ihrombin microspheres. Results The thrombin miorospheres at a high, middle and low dose obviously shortened hemorrhage time( P<0.01) and reduced bleeding volume( P<0.05) of rat femoral artery. The hemostasis was enhanced with dose, but without conspicuous dose-effect relationship. The hemorrhage time ( P<0. 01) of broken tails in mice was significantly curtailed by thrombin microspheres in a dose-dependant manner. The hemorrhage time( P<0.05) was obviously shortened and bleeding volume (P<0.01) was lowered by thrombin microspheres at the high, middle and low dose, especially for the high dose. Conclusion Thrombin-chitosan sodium loaded alginate microspheres have obvious hemostasis effects.关键词
壳聚糖/海藻酸钠/凝血酶/止血Key words
Chilosan/ Sodium alginate/ Thrombin/ Hemostasis分类
医药卫生引用本文复制引用
王强,郎轶咏,李峥,戴华..凝血酶-壳聚糖海藻酸钠微球止血作用研究[J].医药导报,2012,31(5):578-580,3.
