应用化学2012，Vol.29Issue(5)：604-607,4.DOI:10.3724/SP.J.1095.2012.00289
丙烯酰胺-β-环糊精毛细管电色谱手性整体柱的制备及应用
Preparation and Application of Acrylamide-β-cyclodextrin Chiral Monolithic Column for Capillary Electrochromatography
摘要
Abstract
With acrylamide-β-cyclodextrin ( AM-β-CD) and glycidyl methacrylate acting as functional monomers, and ethylene glycol dimethacrylate acting as cross-linking agent, the chiral capillary monolithic column of acrylamide-β-cyclodextrin was prepared by in situ polymerization method. The structure and morphology of the monolithic column were characterized by IR and scanning electron microscopy ( SEM). Meanwhile, the stability and reproducibility were also studied. The results showed that the capillary monolithic column of acrylamide-β-cyclodextrin had a good separation ability, and the column efficiency of 47701 plates/m was obtained. In capillary electrochromatography( CEC) mode, the etilefrine hydrochloride enantiomers were firstly separated by the chiral capillary monolithic column of acrylamide-β-cyclodextrin. Herein, the baseline resolutions of the enantiomers were completely reached.关键词
丙烯酰胺-β-环糊精/整体柱/毛细管电色谱/盐酸依替福林Key words
acrylamide-β-cyclodextrin, monolithic column, capillary electrochromatography, etilefrine hydrochloride分类
化学化工引用本文复制引用
吕仁江,丁会敏,李英杰,丁爽,邓磊,侯学功..丙烯酰胺-β-环糊精毛细管电色谱手性整体柱的制备及应用[J].应用化学,2012,29(5):604-607,4.基金项目
黑龙江省自然科学基金资助项目(B200911) （B200911）
