应用化学2012，Vol.29Issue(7)：762-768,7.DOI:10.3724/SP.J.1095.2012.00339
苯基取代的苯并噻唑胺双苯甲酰胺衍生物的合成及生物活性
Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole
摘要
Abstract
Thirteen novel bisamides compounds containing methoxy and benzothiazole were synthesized. Their structures were characterized by 1H NMR, 13C NMR, IR and elemental analyses. Preliminary bioassay showed that some of them exhibited certain anti-CMV activities, and some compounds posed antitumor activity toward PC3 cells in vitro by MTT method. The antiproliferation activity of compound 4f to PC3 cells was 74. 2% at the concentration of 10 μmol/L.关键词
双酰胺/苯并噻唑/甲氧基/生物活性Key words
bisamides, benzothiazole, methoxy, bioactivity分类
化学化工引用本文复制引用
郑玉国,郭晴晴,熊壮,何勇,杨涛,卢平,魏学,薛伟..苯基取代的苯并噻唑胺双苯甲酰胺衍生物的合成及生物活性[J].应用化学,2012,29(7):762-768,7.基金项目
国家自然科学基金(21062005)和贵州省教育厅自然科学研究项目(黔教科2010090)资助项目 （21062005）
