中国病理生理杂志2012，Vol.28Issue(8)：1504-1506,3.DOI:10.3969/j.issn.1000-4718.2012.08.030
VEGF和bFGF在大鼠压疮模型中的表达及其意义
Expression of VEGF and bFGF in rat model of pressure ulcer
摘要
Abstract
AIM: To sludy the effects of vascular endotlhelial growth factor (VEGF) and basic fibroblast growth faclor (bFGF) on the molecular pathogenesis of pressure ulcer. METHODS: SD rats were randomly divided into conlrol group and experiment group. The pressure ulcer model was established by magnetic disk circulating compression method. HE staining was used to observe the pathological changes of the skin in the rats. The expression of VEGF and bFGF in the tissues was detected by immunohistochemical method. RESULTS: The expression of VEGF and bFGF in the tissues of rat III — degree pressure ulcer was lower than that in the surrounding tissues and normal skin ( P < 0. 01). The changes of VEGF and bFGF were consistent (k =0. 58) . CONCLUSION: The expression levels of VEGF and bFGF are decreased in the tissues of rat pressure ulcer, suggesting that they may be the potential key factors in the difficult healing of pressure ulcer.关键词
压疮/磁片循环压迫/血管内皮生长因子/碱性成纤维生长因子Key words
Pressure ulcer/ Magnetic disk circulating compression/ Vascular endothelial growth factor/ Basic fibroblast growth factor分类
医药卫生引用本文复制引用
黄芳,杨晶金,王雪玲,侯勇,张燕萍,金喜强,梁勇..VEGF和bFGF在大鼠压疮模型中的表达及其意义[J].中国病理生理杂志,2012,28(8):1504-1506,3.基金项目
浙江省自然科学基金资助项目(No.Y2111061) （No.Y2111061）
