中国当代儿科杂志2012，Vol.14Issue(5)：344-349,6.
黄芪及其复方中药治疗小儿β地中海贫血的前瞻性临床研究
Prospective clinical study of radix astragali and its compound prescription for treatment of β-thalassemia in children
摘要
Abstract
Objective To evaluate the efficacy and safety of radix astragali and its compound prescription for treatment of β-thalassemia in children. Methods This study was a randomized, controlled, double-blind clinical trial. Fifty-seven children with pVthalassemia were randomly assigned to radix astragali, compound prescription (radix astragali + codonopsis pilosula + tortoise plastron) and placebo control groups after stratifying the patients according to disease type (intermedia and major). The parameters of hematology and safety were assessed after 12 weeks of treatment. Results After 12 weeks of treatment, the mean Hb elevation levels in children with β-thalassemia intermedia from the compound prescription and the radix astragali groups were 1.21 ±1. 12 and 1.05 ±0. 80 g/dL respectively compared with - (0.28 ± 0.51) g/dL in the placebo control group (P < 0.01). Mean Hb levels in the compound prescription and radix astragali groups were significantly higher than in the placebo control group (P < 0.05). Therapy with both radix astragali and its compound prescription increased fetal hemoglobin, red blood cell, mean corpuscular hemoglobin and reticulocyte levels in children with β-thalassemia intermedia. The total effective rates were 64% and 62% in children with pMhalassemia intermedia from the compound prescription and radix astragali groups respectively, which was significantly higher than in the placebo control group (9% 5 P <0.01). Therapy with radix astragali or its compound prescription in children with p-thalassemia major had similar but less favourable effets than the same therapy in children with β-thalassemia intermedia. White blood cell, neutrophil, platelet and hepatic and renal functions were not adversely affected by the medicines. Conclusions Therapy with radix astragali or its compound prescription is effective and safe in children with ($-thalassemia.关键词
β地中海贫血/黄芪/疗效/胎儿血红蛋白/儿童Key words
β-thalassemia/ Radix astragali/ Efficacy/ Fetal hemoglobin/ Child分类
医药卫生引用本文复制引用
卢焯明,钱新华,陈致雯,张春红,郭丽珊,陈佳..黄芪及其复方中药治疗小儿β地中海贫血的前瞻性临床研究[J].中国当代儿科杂志,2012,14(5):344-349,6.基金项目
广东省中医药局科研课题(编号:2010285) （编号:2010285）
广东省科学技术厅-广东省中医药科学院联合科研专项(编号:2011B032200002). （编号:2011B032200002）
