中国动脉硬化杂志2012，Vol.20Issue(8)：719-722,4.
不同类型肥胖者血清内脂素水平与动脉硬化的相关性
Association of Serum Visfatin and Arterial Stiffness in the Population with Different Obese Type
摘要
Abstract
Aim To investigate the senim level of visfatin in the population with different obese type, and to analyse the relationship and clinical significance between visfatin and arterial stiffness. Methods The basic information was collected in a total of 1063 subjects who were enrolled by the physical examination center of the second people' s hospital of changzhou. Obesity measured by bioelectric impedance analysis, and divided the study population into four groups, based on percent of body fat and waist to hip ratio: normal, normal body weight but viscerally obese, excessive body weight but not viscerally obese, and excessive body weight and viscerally obese. Arterial stiffness was assessed by brachial-ankle PWV(baPWV). Fasting serum visfatin was tested by ELJSA. Results Comparison of the normal body weight group, the levels of serum visfatin and mean baPWV were significantly higher in the obese group, especially in the viscerally obese group (P<0.05). The serum levels of visfatin was positively correlated with baPWV, systolic BP, diastolic BP, hs-CRP(r= 0.366, 0.217, 0. 138, 0.253, respectively, P<0.05). In a multivariate regression analysis, baPWV was independently determined by systolic BP ( P < 0. 01 ) , age ( P < 0. 01 ) , hs-CRP ( P < 0. 01 ) , serum visfatin ( P < 0.01), WHR(P<0.01), diastolic BP(P = 0.01), FPG(P=0. 016). Adjusted R2 of the model was 0.765. Con-chision The result suggest that the elevated level of visfatin is associated with systemic inflammation and artery stiffness in viscerally obese. The visfatin may act as a prediction factor in the cardiovascular disease.关键词
内脂素/肥胖/炎症/胰岛素抵抗/动脉僵硬度Key words
Visfatin/Obesity/Inflammation/Insulin Resistance/Arterial Stiffness分类
医药卫生引用本文复制引用
宋雨,丁志坚,葛继勇,莫婷燕..不同类型肥胖者血清内脂素水平与动脉硬化的相关性[J].中国动脉硬化杂志,2012,20(8):719-722,4.基金项目
江苏省常州市卫生局青年课题(QN200803) （QN200803）
