中国动脉硬化杂志2012，Vol.20Issue(8)：727-730,4.
血清YKL-40水平与2型糖尿病患者冠状动脉病变程度的相关性
Association Between Serum YKL-40 Level and Degree of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus
郑建雷 1孙政 2陆林 2张奇 2张瑞岩 2沈卫峰2
作者信息
- 1. 浙江省人民医院心内科,浙江省杭州市310014
- 2. 上海交通大学医学院附属瑞金医院心内科,上海市200025
- 折叠
摘要
Abstract
Aim To investigate the association between serum YKL-40 and degree of coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Methods 197 patients with type 2 diabetes mellitus undergoing coronary angiography because of angina-like symptoms were divided into control group ( n = 89 ) and CAD group ( n = 108 ) according to the absence or presence of significant coronary stenosis (luminal diameter narrowing of ^50% ). The degree of CAD was graded as single-, double- or three-vessel disease, and Gensini score was used to evaluate the extent of CAD. Serum YKL-40 and high sensitivity C-reactive protein (hs-CRP) levels were assessed by ELISA. Results Compared with control group, CAD patients were more cigarette smoker and had higher systolic blood pressure and serum levels of total cholesterol (TC) , low density lipoprotein cholesterol (LDLC) , apolipoprotein B (ApoB) , lipoprotein (a) (Lp(a)), 2 h postprandial blood glucose (2h BG), HbAlc, YKL-M), and hs-CRP (all P<0. 05). Serum YKL-40 level was increased in patients with CAD, which was more remarkable in those with two- or three-vessel disease (P<0.01), and the Gensini score of single-vessel disease was lower than that of two-disease and three-disease vessel ( P < 0.01). Furthermore , significant correlation between serum YKL-40 and Gensini score was observed (r = 0. 611, P <0. 01). Multivari-ate Logistic regression analysis indicated that serum YKL-40 was a risk factor for CAD in patents with 2 diabtetes mellitus (OR = 1.229, 95%CIwas 1.086-1.427, P=0.003). Conclusions YKL40 may be involved in the initiation and development of atherosclerosis in diabetic patients, and serum YKL-40 level is associated with the severity of CAD in patients with type 2 diabetes mellitus.关键词
2型糖尿病/冠状动脉病变/YKL-40Key words
Type 2 Diabetes Mellitus/Coronary Artery Disease/YKL-40分类
医药卫生引用本文复制引用
郑建雷,孙政,陆林,张奇,张瑞岩,沈卫峰..血清YKL-40水平与2型糖尿病患者冠状动脉病变程度的相关性[J].中国动脉硬化杂志,2012,20(8):727-730,4.
