中国动脉硬化杂志2012，Vol.20Issue(8)：744-748,5.
中国汉族人群ATP结合盒转运子A1基因R219K多态性与冠心病关联研究的荟瘁分析
Meta-Analysis of ATP-Binding Cassette Transporter A1 Gene R219K Polymorphism with Coronary Heart Disease in Chinese Han Population
张步春 1刘伟静 1李海玲 1李伟明 1徐亚伟1
作者信息
- 1. 同济大学附属第十人民医院心内科,上海市200072
- 折叠
摘要
Abstract
Aim To evaluate the association of ATP-binding cassette transporter Al (ABCA1) gene R219K polymorphism with coronary heart disease (CHD) in Chinese Han population. Methods Case-control studies published before 31 May 2012 about the association of ABCA1 gene R219K polymorphism and CHD in Chinese Han population were searched. All the literatures were evaluated and abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by Egger' s test and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Stata (version 11.0) were used for Meta-analysis. Results A total of twelve case-control studies were collected, 22S7 cases and 2356 controls were involved in the Meta-analysis. The results indicated that the K219 was significantly associated with CHD (OR =0. 66, 95%CI 0. 55 -0. 80, P <0. 0001) under dominant model and (OR =0.63, 95%CI 0. 53 -0. 75, P<0.00001) under recessive model, respectively. No significant publication bias was found. Conclusions R219K polymorphism in ABCA1 gene is associated with susceptibility of CHD and K allele might be a protective factor for CHD in Chinese Han population.关键词
ATP结合盒转运子1/基因多态性/冠心病/Meta分析Key words
ATP-Binding Cassette Transporter Al/Polymorphism/Coronary Heart Disease/Mela-Analysis分类
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张步春,刘伟静,李海玲,李伟明,徐亚伟..中国汉族人群ATP结合盒转运子A1基因R219K多态性与冠心病关联研究的荟瘁分析[J].中国动脉硬化杂志,2012,20(8):744-748,5.
