中国动脉硬化杂志2012，Vol.20Issue(9)：809-813,5.
急性心肌梗死患者全身与局部血浆α防御素1-3水平的变化
Level Change of Local and Systemic Plasma Alpha-Defensin 1-3 in Acute Myocardial Infarction
摘要
Abstract
Aim To investigate whether systemic or local (culprit artery) plasma alpha-defensin 1-3 (DEFA1-3) levels are associated with stable coronary artery disease ( CAD) and acute ST-segment elevation myocardial infarction (STEMI). Methods Systemic or local blood samples were obtained from 122 consecutive male subjects including no CAD (n=31> controls, stable CAD (n=44) and STEMI (n=47). Plasma DEFA1-3 levels were measured by ready-to-use solid-phase enzyme-linked immunosorbent assay (EL1SA) based on the sandwich principle. Results Systemic DEFA1-3 in STEMI were increased compared with no CAD (P<0. 05) and stable CAD (P <0. 05), and systemic DE-FA1 -3 in stable CAD were higher than in no CAD (P < 0.05). However, local and systemic levels of DEFA1 -3 did not differ (P>0.05). Receiver operating characteristic (ROC) analysis revealed that the best cutoff value for systemic DE-FA 1-3 levels discriminating STEMI from no CAD and stable CAD was 136. 3 ng/L with a sensitivity of 77. 2% , a specificity of 66. 7% and an area under the curve (AUC) of 0.717 (95%CI: 0.624 to 0. 811, P =0.000). Conclusion STEMI was associated with increased DEFA1-3 in systemic circulation. Future studies should be directed to their prognostic values for myocardial infarction.关键词
急性心肌梗死/α防御素/炎症因子Key words
Alpha-Defensin 1-3/ Acute Myocardial Infarction/ Inflammation Factor分类
医药卫生引用本文复制引用
赵汉军,颜红兵,李文铮,刘臣,陈艺,周鹏,迟云鹏,王韶屏,宋莉..急性心肌梗死患者全身与局部血浆α防御素1-3水平的变化[J].中国动脉硬化杂志,2012,20(9):809-813,5.基金项目
北京市自然科学基金(7082030),北京市优秀人才基金(20081D0300600080),首都医科大学临床基础合作课题(2007JL42)资助 （7082030）
