中国动脉硬化杂志2012，Vol.20Issue(9)：814-818,5.
冠心病患者内皮祖细胞变化与冠状动脉病变的相关性
The Relationship Between Endothelial Progenitor Cells and Coronary Artery Stenosis in Patients of Coronary Heart Diseases
摘要
Abstract
Aim To investigate the isolation and culture of endothelial progenitor cells from peripheral blood in patients with coronary heart diseases, and to determine cell shape, amount and clusters. And to study the correlation of endothelial progenitor cells (EPC) number and the stenosis degree in coronary artery. Methods Mononuclear cells were isolated from peripheral blood of patients with coronary heart diseases (n =57) and control (n = 30). The isolated cells were cultured. And the correlation of EPC number and the stenosis degree of coronary artery was studied in patients with coronary heart disease. Results The number of EPC was significantly reduced in patients with coronary artery disease (CAD) compared with control subjects ( 23.1 ?1.8 vb 56.7 ?2.4). In addition, the number of cell clusters was also impaired in patients with CHD (14.7 ?. 5 vs 24. 2 ?1.7). EPC number and function were decreased with the degree and extent of coronary artery stenosis. Conclusions The number of cell clusters, proliferative capacity of EPC was significantly reduced in patients with CHD compared with control subjects. The number of EPC have negative correlation with the degree and extent of coronary artery stenosis.关键词
内皮祖细胞/冠心病/细胞数量/冠状动脉病变Key words
Endothelial Progenitor Cells/ Coronary Heart Disease/ Cell Number/ Coronary Artery Stenosis分类
医药卫生引用本文复制引用
方叶青,张松荣,方红城,谢陪益,苏又苏..冠心病患者内皮祖细胞变化与冠状动脉病变的相关性[J].中国动脉硬化杂志,2012,20(9):814-818,5.基金项目
湖南省教育厅2006年度“十一·五”重点项目资助课题(200656) （200656）
