中国动脉硬化杂志2012，Vol.20Issue(9)：849-851,3.
阿托伐他汀对高血脂合并稳定型心绞痛及无症状性冠心病患者血清脂联素及血管内皮功能的影响
Effect of Atorvastatin on Serum Adiponectin and Blood Vessel Endothelium Function in Patients with Hyperlipemia Combined with Stable Angina Pectoris and Asymptomatic Coronary Artery Disease
陈秀娟1
作者信息
- 1. 华中科技大学同济医学院附属武汉中心医院干部一科,湖北省武汉市430014
- 折叠
摘要
Abstract
Aim To observe the effect of atorvastatin on semm adiponectin and blood vessel endothelium function in patients with hyperlipemia combined with stable angina pectoris and asymptomatic coronary artery disease. Method 150 cases with hyperlipemia combined with stable angina pectoris and asymptomatic coronary artery disease were randomly divided into three groups. Control group was given conventional treatment of coronary heart disease; observation group I was treated with additional atorvastatin 20 mg/d; observation group II received additional atorvastatin 40 mg/d. The treatment duration was 12 weeks. Fasting venous blood was collected to delect serum levels of adiponectin, serum amyloid A,nitric oxide and endothelin-1. The changes of nitric oxide and endothelin-1 were used as indirect indexes for blood vessel endothelium function. Results After treatment, serum levels of adiponectin and nitric oxide were increased , but endothelin-1 and serum amyloid A were decreased in observation group I and II (all P <0.05 ) , with significantly greater changes of each index in observation group II than those in group I . Serum adiponectin correlated significantly with nitric oxide, and was inversely related to endothelin-1 and serum amyloid A. Conclusion Atorvastatin improves blood vessel endothelium function via reduction of serum adiponectin level. This agent may play an important role in the prevention of atherosclerosis.关键词
阿托伐他汀/脂联素/冠心病Key words
Atorvastatin/ Adiponectin/ Coronary Heart Disease分类
医药卫生引用本文复制引用
陈秀娟..阿托伐他汀对高血脂合并稳定型心绞痛及无症状性冠心病患者血清脂联素及血管内皮功能的影响[J].中国动脉硬化杂志,2012,20(9):849-851,3.
