中国临床药理学与治疗学2012，Vol.17Issue(4)：403-407,5.
土茯苓等中药抑制URAT1表达及降尿酸作用筛选研究
Inhibiting URAT1 gene expression and reducing blood uric acid level of Chinese Traditional Medicine such as smilax glabra
摘要
Abstract
AIM: To explore whether Chinese Traditional Medicine such as alismatales, plan-taginaceae and smilax glabra can regulate the hy-peruricemia mice uric anionic exchanger 1 (URAT1) mRNA expression of rats. METHODS: The 48 Wistar rats were randomly divided into control group, model group, benzbromar-one group, alismatales group, plantaginaceae group and smilax glabra group. There were 8 rats every group. Alismatales, plantaginaceae, smilax glabra and benzbromarone were given to rats with hyperuricemia model established with potassium oxonate. The quantitative Real time PCR method was used for detection of URAT1 mRNA gene expression. RESULTS; The blood uric acid level of benzbromarone group, alismatales group, plantaginaceae group and smilax glabra group were significantly lower than those in the model group (P<0. 01). The expression of URAT1 mRNA in benzbromarone group, plantaginaceae group, benzbromarone group were lower than those in model group. CONCLUSION- The mechanism for plantaginaceae and smilax glabra may be relevant in inhibiting URAT1 gene mRNA expression of rats, thus accelerating the excretion of uric acid.关键词
土茯苓/车前子/尿酸/URAT1/基因表达Key words
Plantaginaceae/ Smilax glabra/Uric acid/URATl/Gene expression分类
医药卫生引用本文复制引用
孙红,王少明,庄捷,黄旭慧,姚锦州..土茯苓等中药抑制URAT1表达及降尿酸作用筛选研究[J].中国临床药理学与治疗学,2012,17(4):403-407,5.基金项目
福建省卫生厅青年科研基金(2010-1-3) （2010-1-3）
