摘要
Abstract
AIM: To study the effect of the change of paw withdrawal thermal latency ( PWTL ) and paw withdrawal mechanical
threshold (PWMT) in high fat-glucose-salt diet-fed rats. METHODS: Thirty five-week-old male Sprague-Dawley rats weighing (100 ± 5) g were
divided into two groups: Group A(n = 20) (high fat-glucose-salt diet-fed) and Group B, the control group (n=10). Food and water available to both groups were not limited. FBG ( fasting blood glucose), FINS (the fasting insulin), PWTL, PWMT, blood pressure and the weight were measured at the 1st, 10th, 20th, 30th, 40th, 50th 60th, 70th, 120th day. RESULTS:(1) No change of FBG were found in the two groups. (2) Group A were significantly high in FINS after 20 days feeding, while that of the group B didn't change. The difference became increasingly remarkable on the 20th, 30lh, 40lh, 50th, 60th, 70th and 120th day. (3) after 70 days feeding, PWTL of group A ( P < 0. 05 ) obviously decreased, whereas that of group B didn't. (4) PWMT of group A decreased after 60 days feeding (P<0. 05), while that of group B didn't.
(5)The blood pressure of group A was noticeably higher than that of group B when measured on the 20th,30th, 40th, 50th, 60th, 70th, 120th day. (6) The weight of both groups increased until the 70th day when significant differences were observed ( P < 0. 05 ). CONCLUSION: High fat-glucose-salt diet can induce high blood pressure, hyperinsulinemic, insulin resistance (on the 20th day), thermal hyperalgesia (on the 70th day) and mechanical hyperalgesia (on the 60th day). But high blood pressure, hyperinsulinemic, insulin resistance didn't appear at the same time with hyperalgesia.关键词
痛阈/热刺激缩足反应潜伏期/机械刺激缩足反应阈值/胰岛素抵抗Key words
Pain threshold/ Paw withdrawal thermal latency/ Paw withdrawal mechanical thresholds Insulin resistance分类
医药卫生
