中国临床药理学与治疗学2012，Vol.17Issue(4)：472-480,9.
HIV蛋白酶抑制剂的药代动力学相互作用
Pharmacokinetic interactions of HIV protease inhibitors
顾融融 1石建 1阿基业 1王广基1
作者信息
- 1. 中国药科大学药物代谢动力学重点实验室,南京,210009
- 折叠
摘要
Abstract
HIV protease inhibitors are the frontline drugs for the management of acquired immune deficiency syndrome during its long-term therapy. A combined medication of HIV protease inhibitors with other drugs is often used when the patients are accompanied with other diseases or complications. As is known, HIV protease inhibitors have extensive pharmacokinetic effects on cytochrome oxidase P450s and transporters so that drug interactions may take place, which are negative to clinic therapy. In this article, we review the relevant reports on
drug interactions between HIV protease inhibitors and other drugs, and amongst themselves, putting more emphasis on mechanism-based pharmacokinetic interaction. Hopefully, this summary can be useful to evaluate clinic regiment designs and improve safety and efficacy of drugs in a combined medication.关键词
HIV蛋白酶抑制剂/相互作用/CYP3A4/P-糖蛋白Key words
HIV protease inhibitors/ Interactions/ CYP450/ P-gp分类
医药卫生引用本文复制引用
顾融融,石建,阿基业,王广基..HIV蛋白酶抑制剂的药代动力学相互作用[J].中国临床药理学与治疗学,2012,17(4):472-480,9.
