中国临床药理学与治疗学2012，Vol.17Issue(6)：659-665,7.
头孢克洛在中国健康志愿者体内的群体药代动力学研究
Population pharmacokinetics of cefaclor in healthy Chinese adult male volunteers
摘要
Abstract
AIM: To develop a population pharmacokinetic model of cefaclor in healthy volunteers and evalute the effect of individual factors on the pharmacokinetics of cefaclor. METHODS: A nonlinear mixed-effect modeling was developed to analyze the data of cefaclor bio-equivalence studies in healthy volunteers and calculate the related parameters and inter- and intra variabilties. RESULTS: two-compartment model with first order absorption was fitted to the cefaclor concentration data. The population value of C0L, V2, V3, KA were 0.219 L/min, 35.9 L, 598 L , 0.042 min-1. respectively. CL was found to be significantly related to the covariate of weight. CONCLUSION: The population pharmacokinetic model can be used to provide accurate individual pharmacokinetic parameters. CL was significantly influenced by the covariate of weight, which showed that it is better to administer drug according to the per kilogram of body weight in clinical practice.关键词
头孢克洛/健康志愿者/群体药代动力学Key words
Amlodipines Healthy Volunteers/ Population Pharmacokinetics分类
医药卫生引用本文复制引用
黄继汉,黄晓晖,王鲲,李俊,郑青山..头孢克洛在中国健康志愿者体内的群体药代动力学研究[J].中国临床药理学与治疗学,2012,17(6):659-665,7.基金项目
国家科技支撑计划项目(2008BAI51B03) （2008BAI51B03）
安徽省优秀青年科技基金(08040106813) （08040106813）
上海市教委创新项目(10YZ61) （10YZ61）
