中国美容医学2012，Vol.21Issue(7)：1163-1165,3.
细胞外信号调节激酶在血管瘤组织中的表达及活性
Expression and activation of extracellular signal regulated kinase in hemangioma
摘要
Abstract
Objective To investigate the protein expression of extracellular signal-regulated kinase1/2 (ERK1/2) and phospho -extracellular signal -regulated kinase1/2 (p -ERK1/2) in hemangiomas,and to explore their role in the development of hemangiomas. Methods The protein expressions of ERK1/2 and p-ERK1/2 in 23 proliferating phase hemangiomas and 19 involuting phase hemangiomas were detected using immunohistochemical method (SP). Results There was no significant difference in the the protein expression of ERK1/2 between proliferating hemangioma and involuting hemangioma ( Z=-0.305,P>0.05). The expression of p-ERK1/2 protein in proliferating hemangioma was significantly higher than that in involuting hemangioma (Z=-4.271, P<0.01). Conclusions The overexpression of p-ERK1/2 and activation of ERK signalling pathway may be related with hemangiomatous proliferation.关键词
血管瘤/细胞外信号调节激酶/磷酸化细胞外信号调节激酶Key words
Hemangioma/ Extracellular signal-regulated kinase1/2, ERK1/2/ Phospho-extracellular signal-regulated kinase1/2, p-ERK1/2分类
医药卫生引用本文复制引用
冯进云,李萍,江贤萍,彭振辉..细胞外信号调节激酶在血管瘤组织中的表达及活性[J].中国美容医学,2012,21(7):1163-1165,3.基金项目
深圳市科技计划项目(编号:201003140) （编号:201003140）
