中国全科医学2012，Vol.15Issue(21)：2408-2410,3.DOI:10.3969/j.issn.1007-9572.2012.07.095
干扰素联合利巴韦林及胸腺肽α1治疗对慢性丙型病毒性肝炎患者外周血T淋巴细胞亚群的影响
Influence of Interferon Combined with Ribavirin and Thymosin Alpha-1 on TLymphocytes Subsets in Peripheral Blood in the Treatment of Chronic Hepatitis C
郭力红 1张岁 1刘静 1段卫 1李保欣 1佟立新1
作者信息
- 1. 050031,河北省石家庄市,河北医科大学第一医院肝病中心
- 折叠
摘要
Abstract
To observe the influence of interferon combined with ribavirin and thymosin alpha - 1 on T lymphocytes subsets in peripheral blood in the treatment of patients with chronic hepatitis C ( CHC ) . Methods 46 patients with CHC were randomly divided into two groups. The treatment group ( 26 cases ) was given thymosin alpha - 1 , with each time 1. 6 mg and twice a week by subcutaneous injection for six months. Besides, the treatment group was also given interferon of 3 million units once every other day by muscle injection as well as ribavirin per os, with each time 0. 4 g, twice a day. The control group was only given interferon combined with thymosin alpha - 1 with the same dosage, usage and course of treatment as the treatment group. The changes of lymphocyte subsets T in peripheral blood among the patients were detected before and after the treatment by using flow cytometry. Results After six months treatment, the CD4 + T cells and CD4 + /CD8 + in treatment group were significantly increased compared with those of the control group ( P < 0. 01 ), while CD8 + T cells were significantly decreased in the treatment group compared with those of the control group ( P<0. 05 ) . Conclusion The combination of interferon, ribavirin and thymosin alpha - 1 have obvious synergy in the treatment of CHC. Disorder of immune function of CD4 + and CD8 + T cells are improved through the therapy of antivirus and immune adjustment.关键词
肝炎,丙型,慢性/干扰素α/利巴韦林/胸腺素/T淋巴细胞亚群Key words
Hepatitis C , chronic/ Interferon - alpha/ Ribavirin/ Thymosin/ T-lymphocyte subsets分类
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郭力红,张岁,刘静,段卫,李保欣,佟立新..干扰素联合利巴韦林及胸腺肽α1治疗对慢性丙型病毒性肝炎患者外周血T淋巴细胞亚群的影响 [J].中国全科医学,2012,15(21):2408-2410,3.
