中国全科医学2012，Vol.15Issue(24)：2790-2793,4.DOI:10.3969/j.issn.1007-9572.2012.08.099
Bcl-2和Hrk及细胞周期素E在胃癌组织中的表达及其意义
Study of the Expression and Biological Significance of Bcl-2,Hrk and Cyclin E in Gastric Cancer
摘要
Abstract
Objective To study the expression and significance of inhibitor of apoptosis protein Bel - 2, apoptosis promote protein Hrk and cell cycle element Cyclin E in gastric cancer. Methods The expressions of Bel - 2, Hrk and Cyclin E in the samples of gastric cancer and adjacent normal tissues of 58 patients with gastric cancer were detected by S - P method. Results Bel -2 protein had positive expression in 38 cases of gastric cancer tissues with a positive rate of 65. 5% , and had positive expression in 14 cases of adjacent normal tissues with a positive rate of 24. 1 %. The difference of positive rate between the two tissues showed statistically significant difference ( x2 = 20. 077, P < 0. 05 ) . Patients with different cancer differentiation levels , clinical stages and whether having lymph node metastases or not showed statistically significant difference in the positive rate of Bel -2 protein ( P <0. 05 ) . Patients with different age, tumor diameter, Borrmann type and infiltration depth showed no statistically significant difference in the positive rate of Bel -2 protein ( P >0. 05 ) . Hrk protein had positive expression in 12 cases of gastric cancer tissues with a positive rate of 20. 7% , and had positive expression in 36 cases of adjacent normal tissues with a positive rate of 62. 1 %. The difference of positive rate between the two tissues showed statistically significant difference ( x2= 20. 471 , P < 0. 05 ) . Cyclin E protein had positive expression in 34 cases of gastric cancer tissues with a positive rate of 58. 6% , and had positive expression in 11 cases of adjacent normal tissues with a positive rate of 18.9%. The difference of positive rate between the two tissues showed statistically significant difference ( x2 = 19. 206, P <0. 05 ) . Spearman correlation analysis showed that Bcl - 2 protein was negatively correlated with Hrk protein ( r = - 0. 286 , P < 0. 05 ), and was positively correlated with Cyclin E protein ( r =0. 749, P <0. 05 ) . Conclusion The pathogenesis of gastric cancer is closely related to the mutual effect of various proteins and positive and negative signal transduction and regulation in genetic level. Inhibitor of apoptosis protein Bcl - 2, apoptosis promote protein Hrk and Cyclin E are involved in the pathogenesis and development of gastric cancer.关键词
细胞凋亡/基因,Bcl-2/Hrk基因/细胞周期蛋白E/胃肿瘤Key words
Apoptosis/ Genes, Bel - 2 / Genes, Hrk/ Cyclin E/ Stomach neoplasms分类
医药卫生引用本文复制引用
赵文江,杨斌,李勇,周喜元,王志强,路欣,姜秋,陈国伟,郭琳,牛延军,曾高云..Bcl-2和Hrk及细胞周期素E在胃癌组织中的表达及其意义[J].中国全科医学,2012,15(24):2790-2793,4.基金项目
新疆生产建设兵团卫生科技计划基金项目(2011年第16号) （2011年第16号）
