中国输血杂志2012，Vol.25Issue(5)：446-448,3.
四氯化碳造成急性肝损伤大鼠模型的实验研究
CCl4 causing acute liver injury in a rat model
摘要
Abstract
Objective To evaluate the acute liver injury rat model. Methods 40 SD rats were randomly divided into two groups: 10 rats for control group,30 rats for model group.50% CCl, olive oil solution (3 ml/kg) was injected intraab-dominally for model group rats .saline solution (3 ml/kg) was injected into control rats. AST / ALT levels were compared between the two groups at 24 h, 72 h, and one week after the injection of CCl4, or normal saline. The survival rates of two groups at 24 h ,48 h post-model were analyzed. The pathological changes of liver at 24 h post-model were observed. Results The ALT/ AST level difference between model group and control group was statistically significant (P <0.01) at all time points. The survival rate were also statistically significant different between the 2 groups (P <0. 01) at 24 h,and 48 h post-modeL Liver sections revealed acute hepatic necrosis in model group. Conclusion The acute hepatic necrosis model is suitable for further experimental needs.关键词
肝损伤/四氯化碳/大鼠模型/ALT/ASTKey words
Liver injury/CCl4/Rat model /ALT/ AST分类
医药卫生引用本文复制引用
刘赴平,师玲玲..四氯化碳造成急性肝损伤大鼠模型的实验研究[J].中国输血杂志,2012,25(5):446-448,3.基金项目
东莞市科技立项(2008105150148) （2008105150148）
