中国实验动物学报2012，Vol.20Issue(3)：21-24,4.DOI:10.3969/j.issn.1005-4847.2012.03.005
经胸腔镜建立巴马小型猪冠状动脉狭窄模型
Establishment of a Bama miniature swine model of coronary artery stenosis by thoracoscopy
摘要
Abstract
Objective To explore a more effective, stable method to establish animal model of coronary artery stenosis assisted by thoracoscopy. Methods The proximal left anterior descending branch of the left coronary artery (LAD) in Bama miniature swine was ligated permanently using a silk suture by thoracoscopy, and induced LAD stenosis to different degrees. Selective coronary artery angiography was performed postoperatively to evaluate the degree of stenosis by quantitative coronary angiography. Results Among the 20 swines, coronary artery stenosis models were successfully constructed in 18 swines. Ventricular fibrillation occurred in 2 swines during the procedure and they died 8 hours and 48 hours after effective defibrillation, respectively. The results of selective coronary angiography showed that there were LAD stenosis degree 20 - 50% in 7, stenosis degree 50 - 70% in 6, and stenosis degree 70 - 90% in 5 swines. The success rate of operation was 100% , and the success rate of model construction was 90% . Conclusions Full-thoracoscopic operation can be successfully used to construct animal models of coronary artery stenosis to different degrees with less injury than open thoracic surgery.关键词
冠状动脉/狭窄/猪/胸腔镜Key words
coronary artery/ stenosis/ swine model/ Thoracoscopy分类
生物科学引用本文复制引用
张海涛,罗惠兰,朴龙松,刘朝中,田毅,陈浩,甘适,张超..经胸腔镜建立巴马小型猪冠状动脉狭窄模型[J].中国实验动物学报,2012,20(3):21-24,4.基金项目
全军“十二五”重点课题(编号:BWS11J054). （编号:BWS11J054）
