中国实验动物学报2012，Vol.20Issue(3)：65-67,后插8,4.DOI:10.3969/j.issn.1005-4847.2012.03.014
雷洛昔酚对大鼠垂体的作用
Effects of raloxifene on the pituitary gland in rats
刘丽娜 1王旭东 1郑魏 1陈丽 1吴梅清 1杨二静 1徐春2
作者信息
- 1. 航天中心医院,北京100049
- 2. 武警总医院,北京100039
- 折叠
摘要
Abstract
Objective To explore the effects of raloxifene on pituitary gland in rats. Methods Ovariectomized Wistar female rats were implanted with silastic tubes containing raloxifene, 17-β estradiol or blank silastic tube alone, re-spec tiyely. After 8 weeks, all the rats were weighed and sacrifieced. The pituitary glands were collected and weighed. Serum prolactin level (PRL) was tested by solid phase-sandwich method. Results There was no significant difference between the pituitary weights of the raloxifene and control groups. However, the pituitary weight of the estrogen group was significantly higher than that of raloxifene and control groups. (both P < 0. 05). The serum PRL level in the estrogen group was significantly higher than that in the raloxifene and control groups (both P < 0.05). The serum PRL level of the raloxifene group was significantly higher than that of the control group (P <0.05). The serum PRL level in the raloxifene group was significantly lower than that of the estrogen group (P < 0.05). Histological examination showed normal pituitary morphology in the raloxifene and control groups, but characteristic changes of prolactinoma were seen in the pituitary gland of estrogen group. Conclusion Raloxifene has a certain impact on rat pituitary gland, but does not induce prolactinoma.关键词
选择性雌激素受体调节剂/雷洛昔酚/雌激素/垂体Key words
Selective estrogen receptor modulator/ Raloxifene/ Estrogen/ Pituitary gland/ Rats分类
生物科学引用本文复制引用
刘丽娜,王旭东,郑魏,陈丽,吴梅清,杨二静,徐春..雷洛昔酚对大鼠垂体的作用[J].中国实验动物学报,2012,20(3):65-67,后插8,4.
