中国实用儿科杂志2012，Vol.27Issue(6)：428-431,4.
儿童肾病综合征合并血栓栓塞23例回顾分析
Nephrotic syndrome complicated with thromboembolism in children -retrospective analysis of 23 cases
陈鹭 1王辉 1沈颖1
作者信息
- 1. 首都医科大学附属北京儿童医院肾脏内科,北京100045
- 折叠
摘要
Abstract
Objective To discuss the clinical manifestations and therapeutic methods of nephrotic syndrome(NS) complicated with thromboembolism(TE) in children. Methods The clinical data of NS complicated with TE between 2006 and 2010 were retrospectively analysed. Gender, the onset age of TE, site, clinical manifestations, blood/urine indices, the course of NS, the use of steroids and curative effects were investigated. Results Totally 23 cases of NS complicated with TE were found in our study. The ratio of boys to girls was 4.75:1 and the average age was (8.17 ± 4.12) years old. There was 1 case with arterial thrombosis, 14 cases with venous thrombosis and 9 cases with embolism. In these 23 cases,urinary protein quantity for 24 hours was (132.65±46.79) mg/(m2 · h) and serum albumin was (12.73± 4.06 )g/L. The elevation of fibrinogen and D-dimer were seen in 18 and 22 children respectively. Symptoms, coagulative function and imaging performances were improved in 22 children, 1 child gave up treatment for economic difficulties. There was no thrombolysis-related adverse event. Conclusion The diagnosis of TE should be considered when nephrotic syndrome is complicated with massive proteinuria, hypoalbuminemia, hypercholesteraemia, using of steroids and diuretics. Fibrinogen and D-dimer increase are predictive for the diagnosis of TE.关键词
肾病综合征/儿童/血栓栓塞/高凝状态Key words
nephrotic syndrome/ child/ thromboembolism/ hypercoagulative state分类
医药卫生引用本文复制引用
陈鹭,王辉,沈颖..儿童肾病综合征合并血栓栓塞23例回顾分析[J].中国实用儿科杂志,2012,27(6):428-431,4.
