中国实用儿科杂志2012，Vol.27Issue(6)：432-435,4.
伴新月体形成儿童原发性IgA肾病临床与病理特点分析
Clinicopathological characteristics of the primary IgA nephropathy with crescentic formation in children
摘要
Abstract
Objective To understand the clinical and pathological characteristics of the primary IgA nephropathy (IgAN) with crescentic formation in children. Methods Clinicopathological data of 78 children with primary igAN were analyzed. These patients were divided into two groups according to with or without crescents, and their results were compared. Results There were 57 male and 21 female patients, with a mean age of (9.32 ±3.16) years old; 33 of them were in Group C (with crescents) and 45 were in Group NC (without crescents). Compared with Group NC,there were significant differences in the course of disease [(2.15 ±4.06)m vs (9.87±19.09)m,P<0.05], macrohematuria (30/33 vs 25/45, P< 0.01), the levels of 24hrs proteinuria[ (93.08 ± 82.75 )mg/(kg·d) vs (44.92 ± 68.44) mg/(kg·d) ,P< 0.05 ], the case number of severe proteinuria (19/31 vs 10/42 , P < 0.01) and occurence of renal impairment (8/33 vs 2/ 45, P<0.01) in Group C. In renal pathology, significantly more cases in Group C had moderate-severe mesangial proliferation, endoeapillary proliferation and tuft adhesion than in Group NC(P<0.01). Immunofluorescence of both Group C and Group NC showed no significant difference. Conclusion The clinical manifestation and renal lesions of IgAN with crescentic formation in childhood are worse than those without, thus we should improve the understanding of this type of IgAN so as to make early diagnosis, treatment and improve the prognosis of this disease.关键词
儿童/原发性IgA肾病/新月体Key words
children/primary IgA nephropathy/crescent分类
医药卫生引用本文复制引用
龚一女,杨青,陈敏广,林瑞霞..伴新月体形成儿童原发性IgA肾病临床与病理特点分析[J].中国实用儿科杂志,2012,27(6):432-435,4.基金项目
温州市科技计划项目(Y20090270) （Y20090270）
