摘要
Abstract
Objective To investigated the importance of anticoagulant therapy during pregnancy with cardiac valve replacement and the impact of warfarin on the embryo and fetus. Methods A retrospective study on 13 cases of pregnant women with mechanical heart valves was to be carried analysis, All these cases were in Affiliated Hospital of Guiyang Medical College and Cuizhou Provincial People Hospital between October 1995 and February 2008. Results 8 cases of pregnancy regulated warfarin anticoagulant therapy, the second trimester because of heart failure after valve replacement line beginning warfarin therapy 1 case. The eight cases of anticoagulant treatment had no maternal complications. 4 cases reduced the amount of warfarin of progestation to 1/2,concurrent valve thrombosis, heart failure 1 case, 1 case of postpar-tum hemorrhage. The dosage of warfarin <5mg/d. 1 case stopped using warfarin five years progestation by herself, complicated with valve thrombosis, heart failure and death. Fetal outcome: abortion, bydrocephahis each2 cases,fatal death 3 cages,including one case of maternal mortality while fetal loss,and warfarin syndrome 1 case. 5 cases was normal children. Conclusion (1) The incorrect anticoagulant therapy during pregnancy will lead a higher proportion of complications and adverse pregnancy outcomes. (2) Warfarin will impact on fetal development, at least in early pregnancy and after 36 weeks its proposed to stop anticoagulant warfarin, the proposed use of anticoagulant heparin.关键词
瓣膜置换术/抗凝/妊娠/华法林Key words
valve replacement/ anticoagulant/ pregnancy/ warfarin分类
医药卫生
