中国药房2012，Vol.23Issue(24)：2221-2225,5.DOI:10.6039/j.issn.1001-0408.2012.24.06
西酞普兰与阿米替林治疗卒中后抑郁障碍的Meta分析
Meta-analysis of Citalopram and Amitriptyline for Post-stroke Depression
摘要
Abstract
OBJECTIVE: To evaluate the efficacy and safety of citalopram and amitriptyline for post-stroke depression (PSD). METHODS: Randomized controlled trials (RCT) focused on citalopram vs. Amitriptyline in the treatment of PSD were searched from the databases including: Cochrane Library, Medline, Embase, CBM, VIP, CNKI and Wanfang database. The qualities of included RCTs were evaluated by means of RevMan 5.1 to conduct the Meta-analysis. RESULTS: A total of 18 RCTs were included, involving 1 040 PSD patients. Meta-analysis results disclosed that the effectiveness of citalopram group was better than that of amitriptyline group after 6 weeks treatment [RR=1.10, 95%CI (1.02,1.18), P=0.01]; the effectiveness of the 2 groups had no significant differences after 8 weeks treatment [RR=1.05, 95%CI(0.97,1.14) ,P=0.09]; compared with amitriptyline group, citalopram group not only presented advantages that improvement of Hamilton Depression Rating Scale score after 1, 2, 4, 6 weeks treatment, but also existed advantages that improvement of side effects scale score 2, 4, 6, 8 weeks after treatment. CONCLUSION: The effect of citalopram is equivalent to amitriptyline, whereas it's faster and safer than amitriptyline in the treatment of PSD.关键词
西酞普兰/阿米替林/卒中后抑郁障碍/有效性/安全性/Meta分析Key words
Citalopram/ Amitriptyline/ Post-stroke depression/ Efficacy/ Safety/ Meta-analysis分类
医药卫生引用本文复制引用
陈亮,谢亮,卢葭,周新雨,郭菁,房亮,谢鹏..西酞普兰与阿米替林治疗卒中后抑郁障碍的Meta分析[J].中国药房,2012,23(24):2221-2225,5.基金项目
科技部重大科学研究计划资助项目(2009CB918300) （2009CB918300）
