中国药房2012，Vol.23Issue(24)：2259-2260,2.DOI:10.6039/j.issn.1001-0408.2012.24.21
氨氯地平联合辛伐他汀逆转高血压左心室肥厚的临床观察
Clinical Efficacy of Amlodipine Combined with Simvastatin on Reversal Left Ventricular Hypertrophy in Hypertension Patients
王煜1
作者信息
- 1. 淄博市第一医院心内科,山东淄博255200
- 折叠
摘要
Abstract
OBJECTIVE: To verify and investigate whether simvastatin could reverse left ventricular hypertrophy and improve left ventricular function. METHODS: 165 hypertension patients with left ventricular hypertrophy were collected from our hospital during Mar. 2008 —Aug. 2010. They were randomly divided into 2 groups, I.e. Amlodipine group (5mg·d-1) and amlodipine (5 mg·d-1) combined with simvastatin (10 mg·d-1) group. Before treatment and at the end of following-up, the structure of the heart was measured by using Siemens color Doppler echocardiogram. RESULTS: After treatment, systolic and diastolic pressures of patients in 2 groups were declined (P<0.05). There was no statistical significance in systolic and diastolic pressures before and after treatment (P>0.05). IVST, LVPwT, LVM, LVMKEF and E/A ratio were also decreased significantly (P<0.05). After treatment, the above parameters of amlodipine combined with simvastatin group were further decreased (P<0.05). Amlodipine treatment and amlodipine combined with simvastatin treatment could improve EF and E/A ratio in hypertension patients with left ventricular hypertrophy (P<0.05). Compared with amlodipine group, amlodipine combined with simvastatin could further improved EF and E/A ratio (P<0.05). There was no serious ADRs found in 2 groups. CONCLUSION: Amlodipine combined with simvastatin can reverse left ventricular hypertrophy and improve blood pressure effectively.关键词
氨氯地平/辛伐他汀/高血压/左心室肥厚/心功能Key words
Amlodipine/ Simvastatin/ Hypertension/ Left ventricular hypertrophy/ Heart function分类
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王煜..氨氯地平联合辛伐他汀逆转高血压左心室肥厚的临床观察[J].中国药房,2012,23(24):2259-2260,2.
