中国药理学通报2012，Vol.28Issue(9)：1196-1199,4.DOI:10.3969/j.issn.1001-1978.2012.09.004
快速老化小鼠SAMP10的老化特征及其研究进展
Aging characteristics and progress in studies on senescence accelerated mouse prone 10(SAMP10)
摘要
Abstract
The senescence-accelerated mouse have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by Professor Takeda coming from Kyoto University in Japan. By aging characteristics, the SAM strains may divide into senescence-prone inbred strains ( SAMP ) and senescence-resistant inbred strains ( SAMR ). As a strain of SAMP strains, the characteristics of senescence-accelerated mouse prone 10 ( SAMP10 ) is aging-related impairment of learning and memory defects. The characteristics of senescence-accelerated mouse prone 10( SAMP10 ) is considered an effective model for studying Alzheimer' s disease ( AD ), which has some pathological characteristics such as beta-amyloid deposition, brain atrophy, nerve DNA damage, astrocytes and microglial cell proliferation, and it has shown certain aging changes in behavior, neurotrans-mitter and molecular levels. The SAMR1 strain is usually used a normal control model which exhibits normal aging characteristics. The SAMP10 can be used as an animal model for the study of revealing mechanism of accelerated deficits in learning and memory, and evaluating of anti-aging drugs and antidepressant drugs.关键词
快速老化小鼠SAMP10/阿尔采末病/动物模型/病理变化/衰老变化/学习记忆Key words
senescence-accelerated mouse prone 10/ Alzheimer s disease/ animal model/ pathological changes/ aging changes / learning and memory分类
医药卫生引用本文复制引用
高琳娜,毕明刚..快速老化小鼠SAMP10的老化特征及其研究进展[J].中国药理学通报,2012,28(9):1196-1199,4.基金项目
国家自然科学基金资助项目(No 30772750) （No 30772750）
