中国药理学通报2012，Vol.28Issue(9)：1285-1288,4.DOI:10.3969/j.issn.1001-1978.2012.09.023
xy9902抗大鼠心肌重构作用的实验研究
Experimental study of xy9902 on rat myocardial remodeling
摘要
Abstract
Aim To investigate the effects and mechanisms of xy9902 on myocardial remodeling induced by pressure overload in rats. Methods Abdominal aortic constriction ( AAC ) method was applied to establish myocardial remodeling models. Captopril (10 mg · kg-01· d-1 ) and xy9902 ( 10 mg · kg-1 · d-1 ) were administered intragastrically for treatment. Collagen content in myocardium was determined by reforming Mallory' s staining. Superoxide dismutase ( SOD ) activity and malonicdialdehyde ( MDA ) content were determined by xanthine oxidase and 2-thiobarbituric acid respectively. Results Myocardial cells distributed disorder, filaments breakage, and collagen hyperplasia in AAC group, but these phenomenon turned to better in Captopril and xy9902 groups. Compared with sham group, SOD activity was down-regulated but MDA content was up-regulated in AAC group( P <0. 01 ); however, SOD activity was up-regulated but MDA content was down-regulated in Captopril and xy9902 groups( P < 0. 01 ). Furthermore, Correlation analysis showed that CVF was negatively correlated with the ratio of SOD/MDA( r = - 0. 801, P < 0. 01 ). Conclusion Xy9902 can prevent myocardial remodeling, and the disproportion of SOD and MDA may be one of the molecular mechanisms.关键词
SERMs/心肌重构/心脏指数/胶原容积分数/Mallory染色/氧化应激Key words
SERMs/ myocardial remodeling/ cardiac index/ collagen volume fraction/ Mallory' s staining/ oxidative stress分类
医药卫生引用本文复制引用
曾菊绒,胥晓丽,侯进,弥曼,熊晓云,徐天娇,于晓江,臧伟进..xy9902抗大鼠心肌重构作用的实验研究[J].中国药理学通报,2012,28(9):1285-1288,4.基金项目
国家自然科学基金重点项目(No 30930105) （No 30930105）
陕西省教育厅科学研究计划项目(No 112L053) （No 112L053）
西安医学院扶植项目(No 10FC14) （No 10FC14）
西安医学院青年基金项目(No 2007QN01) （No 2007QN01）
